Aspergillus Bronchitis in Cystic Fibrosis

http://journal.publications.chestnet.org/article.aspx?articleid=1084530
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The use of itraconazole oral solution formulation is preferred in patients with CF, as higher itraconazole blood concentrations are achieved than with the capsule formulation. The absorption of the solution is more rapid in the fasting state. Conway et al16demonstrated that the administration of oral itraconazole solution, 2.5 mg/kg bid, in patients with CF achieves steady-state concentrations in a maximum of 8 days. Herbrecht et al17 suggested that voriconazole should be the first drug for Aspergillosis