http://www.ucsf.edu/news/2015/02/123461/cystic-fibrosis-discovery-may-lead-new-treatment-strategy-help-patients-breathe
“We thought Pulmozyme would be more effective than NAC in liquefying the mucus, because CF sputum contains lots of DNA,” said Fahy. “But to our surprise, NAC worked much better.”
Saturday, May 9, 2015
Friday, May 8, 2015
Aspergillus Bronchitis in Cystic Fibrosis
http://journal.publications.chestnet.org/article.aspx?articleid=1084530
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The use of itraconazole oral solution formulation is preferred in patients with CF, as higher itraconazole blood concentrations are achieved than with the capsule formulation. The absorption of the solution is more rapid in the fasting state. Conway et al16demonstrated that the administration of oral itraconazole solution, 2.5 mg/kg bid, in patients with CF achieves steady-state concentrations in a maximum of 8 days. Herbrecht et al17 suggested that voriconazole should be the first drug for Aspergillosis
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The use of itraconazole oral solution formulation is preferred in patients with CF, as higher itraconazole blood concentrations are achieved than with the capsule formulation. The absorption of the solution is more rapid in the fasting state. Conway et al16demonstrated that the administration of oral itraconazole solution, 2.5 mg/kg bid, in patients with CF achieves steady-state concentrations in a maximum of 8 days. Herbrecht et al17 suggested that voriconazole should be the first drug for Aspergillosis
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